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Annu Rev Immunol

What to Expect at Each Dose Level Based on the Phase 2 NEJM study (Jastreboff et al., 2023) and the TRIUMPH-4 Phase 3 results

Mechanism and biology Yoshino, Baur, Imai 2018 (Cell Metabolism) and Covarrubias et al

Anaphylaxis is induced antigen cross-linking of antigen-specific IgE antibodies that bind to high-affinity IgE receptors on the surface of basophils and mast cells

While the treatment is relatively painless for most patients, a topical anesthetic can be used

Metabolic Support: Studies indicate it could improve lipid profiles (such as cholesterol and triglyceride levels) while maintaining stable blood glucose and insulin levels